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There are several occupational and non-occupational causes for pleural plaque. It should be noted that plaques are not “pre-cancer” nor are they associated with any measurable effect on lung function. Rosemount Analytical Inc. A Division of Emerson Process Management Instruction Manual IB-106-340C Rev. 4.1 July 2004 Hazardous Area Oxymitter 4000 TOXICOLOGY A number of studies on the health effects of inhalation exposure of rats and hamsters are available. Rats were exposed to RCF in a series of